sulfonylurea receptor 2; ATP-binding cassette transporter sub-family C member 9; ATP-binding cassette C9 (ABCC9, SUR2)

Function: - subunit of ATP-sensitive K+ channels (KATP) - can form cardiac & smooth muscle-type KATP channels with KIR6.2; KIR6.2 forms the channel pore while SUR2 is required for activation & regulation Structure: - belongs to the ABC transporter family, conjugate transporter (TC 3.A.1.208) subfamily - contains 2 ABC transmembrane type-1 domains - contains 2 ABC transporter domains Compartment: membrane (potential) Alternative splicing: named isoforms=2 Pathology: - defects in ABCC9 are the cause of dilated cardiomyopathy 1O

General

ATP-binding cassette sub-family C (ABC transporter-C, ABCC) cell surface receptor glycoprotein phosphoprotein transmembrane 15 protein

Properties

SIZE: MW = 174 kD entity length = 1549 aa COMPARTMENT: plasma membrane MOTIF: exoplasmic domain {1-30} MOTIF: N-glycosylation site {N9} transmembrane domain {31-51} cytoplasmic loop {52-72} transmembrane domain {73-93} exoplasmic loop {94-101} transmembrane domain {102-122} cytoplasmic loop {123-132} transmembrane domain {133-153} exoplasmic loop {154-167} transmembrane domain {168-188} cytoplasmic loop {189-301} transmembrane domain {302-322} exoplasmic loop {323-350} MOTIF: N-glycosylation site {N326} N-glycosylation site {N330} N-glycosylation site {N333} N-glycosylation site {N334} transmembrane domain {351-371} cytoplasmic loop {372-423} transmembrane domain {424-444} exoplasmic loop {445-455} transmembrane domain {456-476} cytoplasmic loop {477-531} transmembrane domain {532-552} exoplasmic loop {553-571} transmembrane domain {572-592} cytoplasmic loop {593-990} MOTIF: ATP-binding site NAME: ATP-binding site SITE: 705-712 transmembrane domain {991-1011} exoplasmic loop {1012-1034} transmembrane domain {1035-1055} cytoplasmic loop {1056-1127} transmembrane domain {1128-1148} exoplasmic loop {1149-1245} transmembrane domain {1246-1266} cytoplasmic domain {12676-1549} MOTIF: ATP-binding site NAME: ATP-binding site SITE: 1346-1353

Database Correlations

OMIM correlations MORBIDMAP 601439 UniProt O60706 PFAM correlations Entrez Gene 10060

References

UniProt :accession O60706