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ATP-binding cassette transporter sub-family C member 11; multidrug resistance-associated protein 8 (ABCC11, MRP8)
Function:
1) metabolism of bile acids, conjugated steroids & cyclic nucleotide
2) enhances the cellular extrusion of cAMP & cGMP
3) stimulates the ATP-dependent uptake lipophilic anions
a) glutathione S-conjugates
- leukotriene C4
b) steroid sulfates
- dehydroepiandrosterone 3-sulfate (DHEAS)
- estrone 3-sulfate
c) glucuronides
- estradiol 17-beta-D-glucuronide
d) monoanionic bile acids
- glycocholate
- taurocholate
e) methotrexate
f) secretion of earwax (putative)
Structure:
- belongs to the ABC transporter family, conjugate transporter (TC 3.A.1.208) subfamily
- contains 2 ABC transmembrane type-1 domains
- contains 2 ABC transporter domains
Compartment: membrane
Alternative splicing: named isoforms=2
Expression:
- expressed in breast, testis > liver, brain, placenta
- not expressed in kidney, spleen, colon
- highly expressed in breast cancer
Polymorphism:
- allele with Arg-184 is responsible for the dry earwax phenotype
General
ATP-binding cassette sub-family C (ABC transporter-C, ABCC)
transmembrane 10 protein
Properties
SIZE: MW = 154 kD
entity length = 1382 aa
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {1-163}
transmembrane domain {164-184}
exoplasmic loop {185-194}
transmembrane domain {195-215}
cytoplasmic loop {216-270}
transmembrane domain {271-291}
exoplasmic loop {292-296}
transmembrane domain {297-317}
cytoplasmic loop {318-383}
transmembrane domain {384-404}
exoplasmic loop {405-417}
transmembrane domain {418-438}
cytoplasmic loop {439-806}
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 544-551
transmembrane domain {807-827}
exoplasmic loop {828-863}
MOTIF: N-glycosylation site {N838}
N-glycosylation site {N844}
transmembrane domain {864-884}
cytoplasmic loop {885-930}
transmembrane domain {931-951}
exoplasmic loop {952-1049}
MOTIF: N-glycosylation site {N992}
transmembrane domain {1050-1070}
cytoplasmic domain {1071-1382}
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 1175-1182
Database Correlations
OMIM 607040
UniProt Q96J66
PFAM correlations
Entrez Gene 85320
References
- UniProt :accession Q96J66
- Protein Spotlight; Of earwax & migration
- Issue 67 of February 2006
http://www.expasy.org/spotlight/back_issues/sptlt067.shtml