ATP-binding cassette sub-family B member 5 (P-glycoprotein ABCB5, ABCB5 P-gp, ABCB5, MDR/TAP)

Function: 1) plasma membrane transporter 2) efflux xenobiotics from cells (rhodamine dye, doxorubicin) Structure: - belongs to the ABC transporter family, MDR subfamily - contains 1 ABC transmembrane type-1 domain - contains 2 ABC transporter domains Compartment: - cell membrane Alternative splicing: named isoforms=2 Expression: - expressed by CD133-expressing progenitor cells among epidermal melanocytes (at protein level) - widely expressed with specific expression in pigment cells Pathology: - expressed in several malignant tissues - role in resistance to doxorubicin of a subset of malignant melanomas - depletion of ABCB5 by RNAi increases sensitivity to several drugs of a subset of melanoma cells

General

ATP-binding cassette sub-family B (ABC transporter-B, ABCB) transmembrane 5 protein

Properties

SIZE: MW = 90 kD entity length = 812 aa COMPARTMENT: cellular membrane MOTIF: exoplasmic domain {1-247} MOTIF: ABC transporter 1 {2-177} transmembrane domain {248-268} cytoplasmic loop {269-291} transmembrane domain {292-312} exoplasmic loop {313-381} transmembrane domain {382-402} cytoplasmic loop {403-471} transmembrane domain {472-492} exoplasmic loop {493-508} transmembrane domain {509-529} cytoplasmic domain {530-812} MOTIF: ABC transporter 2 {570-808} ATP-binding site NAME: ATP-binding site SITE: 605-612

Database Correlations

UniProt Q2M3G0 Entrez Gene 340273

References

UniProt :accession Q2M3G0