alpha-ketoglutarate; 2-oxoglutarate

An intermediate metabolite in the citric acid cycle & in carnitine biosynthesis. Biochemistry: - as an intermediate metabolite in the citric acid cycle - formed from isocitrate via isocitrate dehydrogenase - enzyme: isocitrate dehydrogenase - substrates: isocitrate + NAD⁺ - products: alpha-ketoglutarate + NADH + CO₂ - metabolized to succinyl-CoA by alpha-ketoglutarate dehydrogenase in a reaction that feeds electrons into the electron transport chain via NADH - enzyme: alpha-ketoglutarate dehydrogenase - substrates: alpha-ketoglutarate + NAD⁺ + coenzyme-A - products: succinyl-CoA + CO₂ + NADH * see citric acid cycle for role of alpha-ketoglutarate in citric acid cycle

Related

carnitine biosynthesis citric acid cycle, Krebs cycle or tricarboxylic acid [TCA] cycle

General

glutarate or glutaric acid intermediary metabolite ketone

References

Wikipedia: alpha-Ketoglutaric acid