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tumor necrosis factor, alpha-induced protein 3; DNA-binding protein A20; zinc finger protein A20 (TNFAIP3)
Function:
1) interacts with NAF1
2) inhibits TNF-induced NF-kappa-B-dependent gene expression by interfering with RIP- or TRAF2-mediated transactivation
3) inhibitor of programmed cell death.
4) function of the lymphoid system
a) modulates in vivo effects of TNF
b) induced by TNF-alpha
5) deubiquitinating activity directed towards Lys-48 or Lys-63-linked polyubiquitin chains
6) homodimer
7) interacts with NAF1, TAX1BP1, TRAF2
Structure:
1) belongs to the peptidase C64 family
2) contains 7 A20-type zinc fingers
- contains 1 OTU domain
Compartment: cytoplasm, nucleus
Expression: induced by TNF-alpha
Pathology:
- deletions associated with constitutive activation of NF-kappa B in diffuse large B-cell lymphoma (DLBCL)
General
DNA-binding protein
phosphoprotein
zinc finger protein
Properties
SIZE: entity length = 790 aa
MW = 90 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: binding site
SITE: 58-300
FOR-BINDING-OF: TRAF
MOTIF: OTU (Ovarian TUmor) domain {92-263}
aspartate residue {D100}
cysteine residue {C103}
histidine residue {H256}
domain {286-356}
MOTIF: consensus repeat {286-317}
consensus repeat {324-356}
NAF1 interaction {369-775}
MOTIF: Zinc finger
NAME: Zinc finger
SITE: 381-416
EFFECTOR-BOUND: Zn+2
Zinc finger
NAME: Zinc finger
SITE: 472-507
EFFECTOR-BOUND: Zn+2
Zinc finger
NAME: Zinc finger
SITE: 515-548
EFFECTOR-BOUND: Zn+2
Ser phosphorylation site {S575}
Zinc finger
NAME: Zinc finger
SITE: 601-636
EFFECTOR-BOUND: Zn+2
Zinc finger
NAME: Zinc finger
SITE: 651-686
EFFECTOR-BOUND: Zn+2
Zinc finger
NAME: Zinc finger
SITE: 710-745
EFFECTOR-BOUND: Zn+2
Zinc finger
NAME: Zinc finger
SITE: 756-790
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 191163
UniProt P21580
PFAM correlations
Entrez Gene 7128
Kegg hsa:7128
References
- UniProt :accession P215802
- Compagno M et al
Mutations of multiple genes cause deregulation of NF-B in
diffuse large B-cell lymphoma.
Nature 2009 May 3; [e-pub ahead of print]
PMID: 19412164
http://dx.doi.org/10.1038/nature07968
- SeattleSNPs
http://pga.gs.washington.edu/data/tnfaip3/