Search
serotonin [5HT]-6 receptor; 5-hydroxytryptamine receptor 6; 5-HT-6; serotonin receptor 6 (HTR6)
Function:
- one of several receptors for 5-hydroxytryptamine (serotonin)
- activity is mediated by G proteins that stimulate adenylate cyclase (Gs protein)
- high affinity for tricyclic psychotropic drugs
- controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity
- activator of TOR signaling [3]
- interacts with MTOR, RPTOR & NF1
- interacts with CDK5 (putative)
Structure:
- belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
Expression:
- expressed in several human brain regions, most prominently in the caudate nucleus
Pharmacology:
- idalopirdine, a 5HT6 receptor antagonist, failed to slow cognitive decline in patients with Alzheimer's disease [2]
General
phosphoprotein
serotonin [5HT] receptor
G-protein coupled receptor; serpentine receptor
Properties
SIZE: entity length = 440 aa
MW = 47 kD
COMPARTMENT: synaptic membrane
CELL: neuron
MOTIF: exoplasmic domain {1-34}
transmembrane domain {35-57}
cytoplasmic loop {58-64}
transmembrane domain {65-85}
exoplasmic loop {86-100}
MOTIF: cysteine residue {C99}
MODIFICATION: cysteine residue {C180}
transmembrane domain {101-122}
cytoplasmic loop {123-144}
MOTIF: Tyr phosphorylation site {Y125}
transmembrane domain {145-166}
exoplasmic loop {167-184}
MOTIF: cysteine residue {C180}
MODIFICATION: cysteine residue {C99}
transmembrane domain {185-208}
cytoplasmic loop {209-265}
transmembrane domain {266-290}
exoplasmic loop {291-295}
transmembrane domain {296-320}
cytoplasmic domain {321-440}
Database Correlations
OMIM 601109
UniProt P50406
Pfam PF00001
Entrez Gene 3362
Kegg hsa:3362
References
- UniProt :accession P50406
- Fiore K
NeuroBreak: Alzheimer's Drug Bombs; Elephant Tranquilizer ODs.
MEDPAGE TODAY. Sept 27, 2016
http://www.medpagetoday.com/Neurology/GeneralNeurology/60482
- Meffre J, Chaumont-Dubel S, Mannoury la Cour C et al
5-HT(6) receptor recruitment of mTOR as a mechanism for
perturbed cognition in schizophrenia.
EMBO Mol Med. 2012 Oct;4(10):1043-56
PMID: 23027611 Free PMC Article