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serotonin [5HT]-2B receptor; 5-hydroxytryptamine receptor 2B; 5-HT-2B; serotonin receptor 2B (HTR2B)
Function:
- one of several receptors for 5-hydroxytryptamine (serotonin)
- mediates its action by association with G proteins that activate a phosphatidylinositol-Ca+2 second messenger system
- interacts with MPDZ
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane; multi-pass membrane protein
Expression:
- detected in most peripheral organs
- only low expression levels were found in the brain
General
glycoprotein
serotonin [5HT]-2 receptor
Properties
SIZE: entity length = 481 aa
MW = 54 kD
COMPARTMENT: synaptic membrane
CELL: neuron
MOTIF: exoplasmic domain {1-56}
MOTIF: N-glycosylation site {N30}
transmembrane domain {57-79}
cytoplasmic loop {80-91}
transmembrane domain {92-113}
exoplasmic loop {114-129}
MOTIF: cysteine residue {C128}
MODIFICATION: cysteine residue {C207}
transmembrane domain {130-151}
cytoplasmic loop {152-171}
transmembrane domain {172-192}
exoplasmic loop {193-216}
MOTIF: cysteine residue {C207}
MODIFICATION: cysteine residue {C128}
transmembrane domain {217-239}
cytoplasmic loop {240-324}
transmembrane domain {325-345}
exoplasmic loop {346-360}
transmembrane domain {361-383}
cytoplasmic domain {384-481}
MOTIF: cysteine residue {C397}
MODIFICATION: palmitate
COMPARTMENT: membrane
PDZ recognition motif
NAME: PDZ recognition motif
SITE: 479-481
FOR-BINDING-VIA: PDZ domain
Database Correlations
OMIM 601122
UniProt P41595
Pfam PF00001
Entrez Gene 3357
Kegg hsa:3357
References
UniProt :accession P41595