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serotonin [5HT]-1A receptor; 5-hydroxytryptamine receptor 1A; 5-HT-1A; 5-HT1A; serotonin receptor 1A; G-21 (HTR1A, ADRB2RL1, ADRBRL1)
Function:
- one of the several receptors for 5-hydroxytryptamine (serotonin
- presynaptic autoreceptor
- interaction with serotonin turns off further release of serotonin
- only presynaptic serotonin receptor
- activity is mediated by G proteins that inhibit adenylate cyclase act(Gi proteins)
Structure: belongs to the G-protein coupled receptor 1 family
Compartment:
- cell membrane
- presynaptic autoreceptor on cell body & dendrites
General
glycoprotein
serotonin [5HT]-1 receptor
Properties
SIZE: entity length = 422 aa
MW = 46 kD
COMPARTMENT: synaptic membrane
CELL: neuron
MOTIF: exoplasmic domain {1-36}
MOTIF: N-glycosylation site {N10}
N-glycosylation site {N11}
N-glycosylation site {N24}
transmembrane domain {37-62}
cytoplasmic loop {63-73}
transmembrane domain {74-98}
exoplasmic loop {99-109}
MOTIF: cysteine residue {C109}
MODIFICATION: cysteine residue {C187}
transmembrane domain {110-132}
cytoplasmic loop {133-152}
transmembrane domain {153-178}
exoplasmic loop {179-191}
MOTIF: cysteine residue {C187}
MODIFICATION: cysteine residue {C109}
transmembrane domain {192-217}
cytoplasmic loop {218-345}
transmembrane domain {346-367}
exoplasmic loop {368-378}
transmembrane domain {379-403}
cytoplasmic domain {404-422}
Database Correlations
OMIM 109760
UniProt P08908
Pfam PF00001
Entrez Gene 3350
Kegg hsa:3350
References
- VanDongen AM, Codina J, Olate J, Mattera R, Joho R,
Birnbaumer L, Brown AM.
Newly identified brain potassium channels gated by the guanine
nucleotide binding protein Go.
Science. 1988 Dec 9;242(4884):1433-7.
PMID: 3144040
- UniProt :accession P08908