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3-oxo-5-alpha-steroid 4 dehydrogenase; steroid 5-alpha reductase; testosterone 5-alpha reductase
Catalyzes reduction of testosterone to form dihydrotestosterone.
Pharmacology:
- 5-alpha reductase inhibitors are used for treatment of
- benign prostatic hypertrophy
- androgenic alopecia
Interactions
molecular events
Related
5-alpha reductase inhibitor
Specific
3-oxo-5-alpha-steroid 4 dehydrogenase 1; steroid 5-alpha reductase 1; testosterone 5-alpha reductase 1; SR type 1 (SRD5A1, S5AR)
3-oxo-5-alpha-steroid 4 dehydrogenase 2; steroid 5-alpha reductase 2; testosterone 5-alpha reductase 2; 5 alpha-SR2; type II 5-alpha reductase; SR type 2 (SRD5A2)
3-oxo-5-alpha-steroid 4-dehydrogenase 3; steroid 5-alpha reductase 3; testosterone 5-alpha reductase 3; SR type 3; steroid 5-alpha-reductase 2-like (SRD5A3, SRD5A2L)
General
dehydrogenase
Properties
MOTIF: active site
References
- Melcangi RC, Celotti F, Ballabio M, Poletti A, Martini L.
Testosterone metabolism in peripheral nerves: presence of the
5 alpha-reductase-3 alpha-hydroxysteroid-dehydrogenase
enzymatic system in the sciatic nerve of adult and aged rats.
J Steroid Biochem. 1990 Jan;35(1):145-8.
PMID: 2308325