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3-methylglutaconic aciduria type 5; dilated cardiomyopathy with ataxia

Genetics: - autosomal recessive - associated with defects in TIM17A Clinical manifestations: - early-onset dilated cardiomyopathy - growth failure - cerebellar ataxia causing significant motor delays - testicular dysgenesis - growth failure Laboratory: - 24 hour urine increases in urine organic acids, particularly 3-methylglutaconic acid & 3-methylglutaric acid

General

3-methylglutaconic aciduria