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3-donor embryo

Procedure: - assisted reporduction technology consistng of a mother's oocyte, a father's spermatocytes & mitochondia from a 3rd party donor Clinical significance: - mitochondria from a 3rd party donor replace defective mitochondria in the oocyte cytoplasm during in vitro fertilization - spermatocytes from the father do not donate mitochondria during reproduction - all mitchondria in offspring are derived from mother Notes: - critics fear advent of 'designer babies'

General

assisted reproduction technology (ART)

References

  1. Physician's First Watch, Feb 27, 2014 David G. Fairchild, MD, MPH, Editor-in-Chief Massachusetts Medical Society http://www.jwatch.org - FDA Avisory Committee. Feb 24-25, 2014 2014 Meeting Materials, Cellular, Tissue and Gene Therapies Advisory Committee. http://www.fda.gov/AdvisoryCommittees/CommitteesMeetingMaterials/BloodVaccinesandOtherBiologics/CellularTissueandGeneTherapiesAdvisoryCommittee/ucm380047.htm