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25-hydroxyvitamin D3 deficiency (pseudovitamin D3 deficiency rickets)

Pathology: - vitamin D 25-hydroxylase deficiency Genetics: - associated with defects in CYP2R1 Clinical manifestations: - rickets at a young age despite a history of adequate vitamin D intake Laboratory: - low serum Ca+2 - low serum phosphate - elevated serum alkaline phosphatase activity - low levels of serum 25-hydroxyvitamin D3

General

enzyme deficiency

Database Correlations

OMIM 600081

References

OMIM :accession 600081