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14-3-3 protein (KCIP-1)

The 14-3-3 family of proteins are highly conserved & found in a broad range of organisms, including higher eukaryotes Function: - the protein 14-3-3 family is multifunctional & may represent a novel type of chaperone [2] - allegedly stimulates import of precursor proteins into the mitochondria - interactions with other cellular proteins may be stabilizing in nature - the beta & zeta isoforms of 14-3-3 interact with raf1 kinase & with protein kinase C [2] - 14-3-3 proteins activate tyrosine hydroxylase after it has been phosphorylated by CAM kinase II, perhaps through stabilization of the phosphorylated form of the enzyme - the beta & zeta isoforms are presumably phosphorylated by proline-directed kinase(s) & the human T-cell isoform tau is phosphorylated on Ser by bcr Structure: - the alpha & delta forms of 14-3-3 are phosphorylated forms of the beta & zeta isoforms, respectively Compartment: - 14-3-3 family proteins are localized in neurons & are axonally transported to nerve terminals Expression: - expressed in neurons - stratifin or HME1 is a 14-3-3 family member found in human epithelial cells [2] Laboratory: - protein 14-3-3 in cerebrospinal fluid

Interactions

molecular events

Specific

14-3-3 protein beta/alpha; protein kinase C inhibitor protein 1; KCIP-1; protein 1054 (YWHAB) 14-3-3 protein epsilon; 14-3-3E (YWHAE) 14-3-3 protein eta; protein AS1 (YWHAH YWHA1) 14-3-3 protein gamma; protein kinase C inhibitor protein 1; KCIP-1 (YWHAG) 14-3-3 protein sigma; stratifin; epithelial cell marker protein 1 (SFN HME1) 14-3-3 protein theta; 14-3-3 protein tau; 14-3-3 protein T-cell; protein HS1 (YWHAQ) 14-3-3 protein zeta/delta; protein kinase C inhibitor protein 1; KCIP-1 (YWHAZ)

General

oligomerizing protein phosphoprotein

Properties

SIZE: MW = 30 kD MOTIF: binding site SITE: N-TERMINAL FOR-BINDING-OF: 14-3-3 protein Ser phosphorylation site MOTIF-SEQUENCE: SPEK Ser phosphorylation site binding site FOR-BINDING-OF: raf1 proto-oncogene protein FOR-BINDING-VIA: Zinc finger

References

  1. prosite :accession {PS00796 PS00797}
  2. Aitken A. 14-3-3 proteins on the MAP. Trends Biochem Sci. 1995 Mar;20(3):95-7. PMID: 7709434

Component-of

molecular complex